Split limb phenomenon in amyotrophic lateral sclerosis: electrophysiologic study

Abstract Background Amyotrophic lateral sclerosis (ALS) is a degenerative disease that affects the upper and lower motor neurons. The onset of frequently focal, usually involving distal segments extremities. A dissociated pattern muscle atrophy commonly found in hands feet. This study aims to investigate presence (if any) split indices ALS patients correlate these with confounding factors. total 48 people were studied. control group consists 24 another age- gender-matched patients. To assess functional status strength, rating scale (ALSFRS) Medical Research Council (MRC) used, respectively. Sensory nerve conduction, as well compound action potential (CMAP) amplitude, recorded from muscles limbs. electromyographic (EMG) activity 20 unit potentials (MUAPs) four different areas was also Results Distal CMAP amplitude reduced all tested (especially noticed when comparing reciprocal muscles). In patients, foot index (SFI) significantly higher, while elbow (SEI) lower. be negatively related duration, but positively ALSFRS scores. MRC score. Conclusion Ankle dorsiflexion are more involved (dissociated) than plantar flexor muscles, flexors extensors. SFI correlates duration